0888 Individuals with REM sleep behavior disorder show increased parkinsonism with comorbid neurotrauma: A NAPS Consortium substudy

Abstract Introduction Introduction: Rapid eye movement (REM) sleep behavior disorder (RBD) is strongly associated with progressive phenoconversion to an overt synucleinopathy (e.g., parkinsonism). Neurotrauma [i.e., traumatic brain injury (TBI) and posttraumatic stress (PTSD)], increases the odds of RBD diagnosis by ~2.5-fold increased later Parkinson’s Disease (PD), a service-connected illness in Veterans. Thus, neurotrauma are both independently parkinsonism; however, it unclear how influences neurological symptoms exam findings patients RBD. Methods Methods: Participants ≥18 years age overnight polysomnogram-confirmed were enrolled between 8/2018 4/2021 as part North American Prodromal Synucleinopathy (NAPS) Consortium. Standardized assessments for RBD, TBI, PTSD history, well cognitive, motor, sensory autonomic function completed. This sub-study applied cross-sectional, case-control (1:4 ratio) analysis comparing cases (n=24; RBD+TBI+PTSD) controls (n=96; RBD) matched (±2 years), sex, education years). Results Results: reported earlier symptom onset more severe phenotype, anxiety depression, greater frequency hypertension, significantly worse compared participants without neurotrauma. Conclusion Conclusion: case:control study showed that individuals comorbid have outcomes related common features early parkinsonism. Although confirmatory longitudinal studies still ongoing, these results may be sign further/faster progression those Support (if any) Support: NIH R34 AG056639, U19 AG071754, VA RRD 1K2 RX002947, Parkinsons Center Oregon